From marijuana to psychedelics to the lingering overdose crisis to the emergence of a new vaping-related illness, a lot happened in 2019. Here are ten of the biggest highs and lows.

If we want to address the overdose crisis, we have to look beyond fentanyl and the opioids.

South Dakota is doing some really nasty things in the name of the war on drugs.

Is it time to legalize MDMA? The Beckley Foundation thinks so.

A Tennessee deputy goes on a bizarre crime spree, a California cop gets busted for the fondling the breasts of a dead overdose victim, and more.

Major League Baseball and its players' union have reached a drug testing agreement, Wisconsin's GOP Senate leader kills a medical marijuana bill, and more.

Italy legalizes hemp and CBD products, Trinidad and Tobago moves toward marijuana decrim, New Jersey legislaors are busy on two fronts, and more.

The latest version of California's psilocybin decriminalization initiative turns it into a legalization initiative, a group of Senate Republicans file a bill to treat drug cartels like terrorist organizations, and more.

Protections for state-level marijuana legalization programs gets stripped from a federal funding bill, two new polls have strong national support for legalization, a Dutch political party is pushing for the legalization of Ecstasy and soft drugs, and more.

It looks like Congress will once again block the District of Columbia from taxing and regulating legal marijuana sales, a key Rhode Island senator just says no to legalizing pot there next year, and more.