October 8, 1932: The Uniform State Narcotics Act is passed, endorsed by the federal Bureau of Narcotics as an alternative to federal laws. By 1937 every state prohibits marijuana use.

October 7, 1989: Former US Secretary of State George P. Shultz tells an alumni gathering at Stanford Business School, "It seems to me we're not really going to get anywhere until we can take the criminality out of the drug business and the incentives for criminality out of it. Frankly, the only way I can think of to accomplish this is to make it possible for addicts to buy drugs at some regulated place at a price that approximates their cost... We need at least to consider and examine forms of controlled legalization of drugs... No politician wants to say what I have just said, not for a minute."

October 5, 1999: The war on drugs is "an absolute failure," says Gov. Gary Johnson of New Mexico at a conference on national drug policies at the Cato Institute. Johnson, who drew sharp criticism from anti-drug leaders for being the first sitting governor to advocate legalizing drugs, argues that the government should regulate narcotics but not punish those who abuse them: "Make drugs a controlled substance like alcohol. Legalize it, control it, regulate it, tax it. If you legalize it, we might actually have a healthier society." Johnson also meets with founding members of Students for Sensible Drug Policy; footage from the meeting appears on CBS evening news.

October 6, 2000: Former US President Bill Clinton is quoted in Rolling Stone: "I think that most small amounts of marijuana have been decriminalized in some places, and should be."

October 9, 2000: PBS begins a special two-day program entitled "Drug Wars." The series examines America's ceaseless efforts over the past three decades to stop the flow of illegal drugs into the country, and shows how the drug war wastes hundreds of billions of dollars, alters the criminal justice system, puts millions of people in jail, and allows organized crime to thrive.

October 10, 2002: Drug Czar John Walters travels to Las Vegas, Nevada and begins two days of making appearances around the state illegally lobbying against Question 9, a proposal to amend the state constitution by making the possession of three ounces or less of marijuana legal for adults. The measure is defeated at the polls the following month.

October 7, 2003: Comedian Tommy Chong begins a nine-month federal prison sentence for operating a glass blowing shop that sold pipes to marijuana smokers.