November 15, 1875: San Francisco passes the first US anti-drug law, an ordinance outlawing Chinese opium dens.

November 12, 1970: Keith Stroup forms the National Association for the Reform of Marijuana Laws (NORML).

November 12, 1980: New York City Mayor Ed Koch admits to having tried marijuana.

November 15, 1984: Spanish police arrest Jorge Ochoa on a US warrant and both the U.S. and Colombia apply for his extradition. Soon after, the Medellin cartel publicly threatens to murder five Americans for every Colombian extradition. The Spanish courts ultimately rule in favor of Colombia's request and Ochoa is deported. He serves a month in jail on charges of bull-smuggling before he is paroled.

November 11, 1988: The Anti-Drug Abuse Act establishes the creation of a drug-free America as a policy goal. A key provision of the act is the creation of the Office of National Drug Control Policy (ONDCP) to set priorities, implement a national strategy, and certify federal drug-control budgets.

November 14, 1999: In an editorial, the Lancet, one of the world's leading medical journals, says, "On the medical evidence available, moderate indulgence in cannabis has little ill effect on health."

November 13, 2000: The National Association of Criminal Defense Lawyers (NACDL) releases the final version of its "NACDL Board Resolution to End the 'War on Drugs.'”

November 10, 2001: The Austin American-Statesman reports that police publicly apologized to Maria Flores for a botched drug raid on May 16.

November 15, 2001: Asa Hutchinson, administrator for the Drug Enforcement Administration, and Republican Gov. Gary Johnson of New Mexico debate the war on drugs in front of about 150 people in Yale's Law School auditorium.

November 15, 2002: NFL star and NORML advisory board member Mark Stepnoski is interviewed on the O'Reilly Factor.