October 24, 1968: Possession of psilocybin or psilocin becomes illegal in the US.

October 22, 1982: The first publicly known case of contra cocaine shipments appears in government files in a cable from the CIA's Directorate of Operations. The cable passes on word that US law enforcement agencies are aware of "links between (a US religious organization) and two Nicaraguan counter-revolutionary groups [which] involve an exchange in (the United States) of narcotics for arms." [The material in parentheses was inserted by the CIA as part of its declassification of the cable. The name of the religious group remains secret.]

October 26, 1993: Reuters reports that the National Organization for the Reform of Marijuana Laws (NORML) joined scores of Boy Scout troops, Elks Clubs, and other community groups in a program in which participants clean up sections of Ohio's highway system. The Ohio Department of Transportation denied NORML's application twice previously, arguing it would be helping to advertise a "controversial activist" group. The American Civil Liberties Union stepped in, and Ohio's attorney general forced transportation officials to relent.

October 25, 1997: Regarding Colombia, the New York Times quotes US Drug Czar General Barry McCaffrey as saying, "Let there be no doubt: We are not taking part in counterguerrilla operations." Less than two years later, on July 17, 1999, the Miami Herald reports: "McCaffrey said it was 'silly at this point' to try to differentiate between anti-drug efforts and the war against insurgent groups."

October 26, 1997: The Los Angeles Times reports that twelve years after a US drug agent was kidnapped, tortured and murdered in Mexico, evidence has emerged that federal prosecutors relied on perjured testimony and false information, casting a cloud over the convictions of three men now serving life sentences in the case.

October 23, 2001: Britain's Home Secretary, David Blunkett, proposes the reclassification of cannabis from Class B to Class C. Cannabis is soon decriminalized in Great Britain.

October 26, 2001: DEA agents descend on the LA Cannabis Resource Center, seizing all of the center's computers, files, bank account, plants, and medicine. The DEA cites a recent Supreme Court decision as justification for their action. The patient cannabis garden at the West Hollywood site is seized by DEA agents despite the loud protestations of the West Hollywood Mayor and many local officials and residents.

October 23, 2002: Time/CNN conducts a telephone poll of 1,007 adult Americans over two days (October 23-24), the result: Nearly one out of every two American adults acknowledges they have used marijuana, up from fewer than one in three in 1983.

October 20, 2004: A groundbreaking coalition of black professional organizations comes together to form the National African American Drug Policy Coalition (NAADPC). NAADPC "urgently seeks alternatives to misguided drug policies that have led to mass incarceration."