Methadone and Cipro: Patients Needing Both Should Consult Physicians About Possible Drug Interaction 11/9/01

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According to an article published last year in the British medical journal The Lancet, there is a significant drug interaction between Ciprofloxacin (Cipro), used to prevent and treat anthrax, and methadone, an opiate used to treat heroin addiction and severe pain.

According to The Lancet, Cipro may inhibit the primary enzyme responsible for metabolizing methadone, elevating methadone levels significantly and creating a risk of overdose. This does not mean that methadone patients cannot take Cipro, but it might mean they need to lower their doses.

Any patient taking both methadone and Cipro should discuss this possible interaction with their physician. It's also recommended by that patients using LAAM and Cipro consult with their physicians.

The Lancet article is "Methadone, Ciprofloxacin, and Adverse Drug Reactions," by Karin Herrlin, Marta Segerdahi, Lars L Gustafsson and Eija Kalso, Lancet 356:2069-70, 12/16/2000 Research Letters. It can be read online by registering at thelancet.com and then visiting http://www.thelancet.com/journal/vol356/iss9247/contents/ to download the document.

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