September 21, 1969: In an attempt to reduce marijuana smuggling from Mexico, the Customs Department, under Commissioner Myles Ambrose, acting on the orders of President Richard Nixon, launches Operation Intercept, subjecting every vehicle crossing the Mexican border to a three-minute inspection and to many observers marking the beginning of the modern was on drugs. The operation lasts two weeks and wreaks economic havoc on both sides of the border, but fails to seriously impact the flow of marijuana into the US.

September 19, 1986: Federal Judge H. Lee Sarokin says, "Drug testing is a form of surveillance, albeit a technological one. Nonetheless, it reports on a person's off-duty activities just as surely as if someone had been present and watching. It is George Orwell's Big Brother society come to life."

September 17, 1998: 93 members of Congress vote yes in the first vote on medical marijuana to take place on the floor of the House.

September 20, 1999: The public is finally informed of the results of Washington, DC's Initiative 59, the Legalization of Marijuana for Medical Treatment Initiative of 1998, after Judge Richard Roberts orders the release of the tally previously suppressed by Congress. Voters had supported medical marijuana by 69-31%.

September 17, 2002: Santa Cruz, California, officials allow a medical marijuana giveaway at City Hall to protest federal raids.

September 19, 2002: The Guardian (UK) reports that Mo Mowlam, the former cabinet minister responsible for drugs policy, is calling for the international legalization of the drug trade as part of a more effective drive to combat terrorism.

September 16, 2003: Seattle voters approve Initiative 75 by 57.8% to 42.2%. I-75 instructs local police and prosecutors to make adult marijuana possession their lowest priority.

September 21, 2004: In a speech, U.S. House Speaker Dennis Hastert (R-IL) says, "The illegal drug trade is the financial engine that fuels many terrorist organizations around the world, including Osama bin Laden."