November 1, 1968: The UK's Advisory Committee on Drug Dependence releases the Wootton Report, recommending that marijuana possession not be a criminal offense.

October 27, 1969: Anthropologist Margaret Mead provides testimony to Congress: "It is my considered opinion at present that marihuana is not harmful unless it is taken in enormous and excessive amounts. I believe that we are damaging this country, damaging our law enforcement situation, damaging the trust between older people and younger people by its prohibition, and this is far more serious than any damage that might be done to a few over-users."

October 27, 1970: Congress passes the Comprehensive Drug Abuse Prevention and Control Act. It strengthens law enforcement by allowing police to conduct "no-knock" searches and includes the Controlled Substances Act, which establishes five categories ("schedules") for regulating drugs based on their medicinal value and potential for addiction.

October 28, 1972: In a reelection campaign statement about crime and drug abuse, President Richard Nixon says: "As a result of our total war on drug abuse, the rate of growth in new heroin addiction has declined dramatically since 1969. By next June, we will have created the capacity to treat up to 250,000 heroin addicts annually -- a thirty-fold increase over the amount of federally funded drug treatment which existed when I took office... My goal for the next 4 years is for every American city to begin realizing the kind of victories in the war on crime which we have already achieved in the Nation's Capital -- where the crime rate has been cut in half since my Administration took office, and where heroin overdose deaths have almost disappeared... This kind of progress can and must be made all across America. By winning the war on crime and drugs, we can restore the social climate of order and justice which will assure our society of the freedom it must have to build and grow."

October 27, 1986: President Reagan signs The Anti-Drug Abuse Act of 1986, an enormous omnibus drug bill which appropriates $1.7 billion to "fight the drug crisis." The bill's most consequential action is the creation of mandatory minimum penalties for drug offenses.

October 26, 1993: Reuters reports that the National Organization for the Reform of Marijuana Laws (NORML) joined scores of Boy Scout troops, Elks Clubs, and other community groups in a program in which participants clean up sections of Ohio's highway system. The Ohio Department of Transportation had denied NORML's application twice previously, arguing it would be helping to advertise a "controversial activist" group. The American Civil Liberties Union stepped in, and Ohio's attorney general forced transportation officials to relent.

October 29, 1993: The administrator for the Drug Enforcement Administration (DEA), Robert C. Bonner, resigns after three years in office to enter private law practice in Los Angeles. He disagreed with the Clinton administration's increased emphasis on drug treatment, saying it amounted to a decrease in emphasis on law enforcement and the pursuit of cooperation from foreign governments. "Drug treatment, particularly in this town, is the real feel good (method) for how you deal with the drug problem. It doesn't deal with any enforcement of the laws. It makes everybody feel all warm and fuzzy... I think treatment is being oversold," says Bonner.

October 30, 1995: President Bill Clinton signs legislation passed by Congress rejecting a US Sentencing Commission move to reduce penalties for crack cocaine offenses to bring them equal with powder cocaine.

October 26, 1997: The Los Angeles Times reports that twelve years after a US drug agent was kidnapped, tortured and murdered in Mexico, evidence has emerged that federal prosecutors relied on perjured testimony and false information, casting a cloud over the convictions of three men now serving life sentences in the case.

October 27, 1997: After a four-year investigation and a five-month trial, a federal jury returns a not guilty verdict on one racketeering charge against two former US prosecutors who became lawyers for a drug cartel, but fails to reach verdicts on drug trafficking and other charges against the two lawyers.

October 26, 2001: DEA agents descend on the LA Cannabis Resource Center, seizing all of the center's computers, files, bank account, plants, and medicine. The DEA cites a recent Supreme Court decision as justification for their action. The patient cannabis garden at the West Hollywood site is seized by DEA agents despite the loud protestations of the West Hollywood Mayor and many local officials and residents.

October 27, 2001: The Guardian (UK) reports that a majority of Britons believe cannabis should be legalized and sold under license in a similar way to alcohol. Some 65 percent of those questioned in a poll agree it should be legalized and 91 percent said it should be available on prescription for sufferers of diseases like multiple sclerosis.

October 28, 2002: The New York Post reports that a Time/CNN poll reveals that 72 percent of Americans now feel that people arrested with small amounts of marijuana should not do any jail time, while just 19 percent favored sending pot smokers to jail. Nearly 60 percent of Americans still want marijuana possession to be considered a criminal offense -- but 34 percent now favor complete legalization. The new poll also offers good news to activists and lawmakers who are calling for the legalization of medical marijuana: 80 percent of those surveyed said they favored dispensing pot for medicinal purposes.

October 31, 2002 -- The Washington Post publishes a story about a rare interview with Benjamín Arellano Félix, the man accused of running Mexico's most ruthless drug cartel, from the La Palma maximum security federal prison in Almoloya de Juárez, Mexico. Arellano said the United States has already lost its war on drugs and that violent trafficking gangs will thrive as long as Americans keep buying marijuana, cocaine and heroin.

November 1, 2002: Every prosecutor in the United States is sent a letter from the Office of National Drug Control Policy (ONDCP) and the National District Attorneys Association (NDAA), urging them to make prosecution of cannabis crimes a high priority and to fight efforts to ease drug laws.

October 27, 2004: In an op-ed piece in the Paris newspaper Le Monde, Raymond Kendall, the chief of the international law enforcement agency Interpol from 1985 to 2000, calls drug prohibition "obsolete and dangerous" and says its continuation represents a missed opportunity for reform. He says prohibition has failed to protect the world from drugs and Europe must take the lead in reforming the drug laws, particularly at the United Nations General Assembly Special Session on drugs in Vienna in 2008.