March 18, 1839: Lin Tse-Hsu, the imperial Chinese commissioner in charge of suppressing the opium traffic, orders all foreign traders to surrender their opium. In response, the British send expeditionary warships to the coast of China, initiating the First Opium War.

March 22, 1972: The Richard Nixon-appointed, 13-member National Commission on Marijuana and Drug Abuse recommends the decriminalization of marijuana, concluding, "Marihuana's relative potential for harm to the vast majority of individual users and its actual impact on society does not justify a social policy designed to seek out and firmly punish those who use it."

March 19, 1983: Best known for her role in Just Say No, First Lady Nancy Reagan appears on the NBC sitcom Different Strokes, declaring: "Let me tell you a true story about a boy we'll call Charlie. He was only 14 and he was burned out on marijuana… One day, when his little sister wouldn't steal some money for him to go and buy some more drugs, he brutally beat her. The real truth is there's no such thing as soft drugs and hard drugs. All drugs are dumb... Don't end up another Charlie."

March 17, 1999: A report by the Institute of Medicine for the Office of National Drug Control Policy states that "there is no conclusive evidence that the drug effects of marijuana are causally linked to the subsequent abuse of other illicit drugs" and "scientific data indicate the potential therapeutic values of cannabinoid drugs for pain relief, control of nausea and vomiting, and appetite stimulation."

March 16, 2000: Patrick Dorismond, an unarmed security guard, is shot and killed by undercover New York City police officers who had unsuccessfully tried to sell him marijuana in a "buy-and-bust" operation. [The shooting was the third time in 13 months that New York City police officers dressed in plainclothes shot and killed an unarmed black man. Under Mayor Rudolph Giuliani, marijuana arrests rose from 720 in 1992, to 59,945 in the first eleven months of 2000.]

March 19, 2001: Mexican President Vicente Fox is quoted in the Associated Press: "[T]he day that the alternative of freeing the consumption of drugs from punishment comes, it will have to be done in the entire world because we are not going to win anything if Mexico does it, but the production and traffic of the drugs... to the United States continues. Thus, humanity will one day view it [legalization] as the best in this sense."

March 20, 2002: Reuters reports that British scientists found that motorists who smoke a cannabis joint retain more control behind the wheel than those who drink a glass of wine. Research from Britain's Transport Research Laboratory showed drivers found it harder to maintain constant speed and road position after drinking the equivalent of a glass of wine than after smoking a "spliff."

March 21, 2003: President Bush announces his intention to nominate Karen P. Tandy to be the Drug Enforcement Administration's new administrator. Tandy served in the Department of Justice (DOJ) as Associate Deputy Attorney General and Director of the Organized Crime Drug Enforcement Task Force. She also previously served in DOJ as Chief of Litigation in the Asset Forfeiture Office and as Deputy Chief for Narcotics and Dangerous Drugs. Earlier in her career, she prosecuted drug, money laundering, and forfeiture cases as an Assistant United States Attorney in the Eastern District of Virginia and in the Western District of Washington.