May 1, 1972: Nobel Prize laureate for economics Milton Friedman is quoted in Newsweek: "Legalizing drugs would simultaneously reduce the amount of crime and raise the quality of law enforcement. Can you conceive of any other measure that would accomplish so much to promote law and order?"

April 30, 1984: Colombian Minister of Justice Rodrigo Lara Bonilla, who had crusaded against the Medellin cartel, is assassinated by motorcycle-riding contract killers. President Belisario Betancur, who had opposed extradition, announces, "We will extradite Colombians." Carlos Lehder is the first to be put on the list. The crackdown forces the Ochoa family, Escobar, and Óscar Rodríguez Gacha to flee to Panama for several months. A few months later, Escobar is indicted for Lara Bonilla's murder and the Ochoas and Rodríguez Gacha named as material witnesses.

May 3, 1994: Dear Abby states publicly in her column that "Just as bootleggers were forced out of business in 1933 when Prohibition was repealed, making the sale of liquor legal (thus eliminating racketeering), the legalization of drugs would put drug dealers out of business. It also would guarantee government approved quality, and the tax on drugs would provide an ongoing source of revenue for drug-education programs."

April 29, 1996: At a speech at a Miami high school, President Clinton calls for a war on drugs -- for the second time. General Barry McCaffrey, the nation's drug czar, told the Cleveland Plain Dealer on May 1 that "everything the president has announced is already being done. There's nothing new here."

May 2, 2001: The Louisiana Senate, voting 29-5, passes sweeping legislation to bring relief to an overflowing state prison system, including ending mandatory prison time for possession of small quantities of drugs.

May 1, 2003: The Illicit Drug Anti-Proliferation Act of 2003 (IDAPA) is signed into law, among other things amending a section of the Controlled Substances Act to target rave organizers. It shifts the statute's emphasis from punishing those who establish places where drugs are made and consumed, such as "crack houses," to those who knowingly maintain "drug-involved premises," including outdoor events such as rock concerts. In addition to the criminal penalties in the original statute, the amended statute adds a civil penalty, thereby lowering the standard of proof from beyond a reasonable doubt to a preponderance of evidence.