April 3, 1953: With the support of Allen W. Dulles, director of Central Intelligence, Richard C. Helms proposes funding for a biochemical warfare research program named MKULTRA, which among other things administers LSD to its unknowing participants.

April 2, 1988: The Economist editorializes in favor of bringing drug users within the law by allowing them to purchase limited doses of drugs that have been manufactured and distributed legally.

April 8, 1989: Miguel Angel Felix Gallardo is arrested in Mexico. Guillermo Gonzalez Calderoni leads a team of Federal agents who arrest the drug lord in a residential suburb of Guadalajara. Gallardo is imprisoned on charges relating to the kidnapping and murder of Enrique Camarena. His nephews, the Arellano-Felix brothers, inherit part of his drug-trafficking empire.

April 6, 1995: ABC News airs a special entitled "America's War on Drugs: Searching for Solutions" in which legalization is presented as an alternative to the failing war on drugs.

April 6, 1998: Dr. Dennis Rosenbaum's six year study of 1,798 students, "Assessing the Effects of School-based Drug Education: A Six Year Multilevel Analysis of Project DARE," finds that "DARE had no long-term effects on a wide range of drug use measures," that DARE does not "prevent drug use at the stage in adolescent development when drugs become available and widely used, namely during the high school years," and that "DARE may actually be counterproductive."

April 5, 2000: The Journal of the American Medical Association publishes "Trends in Medical Use and Abuse of Opioid Analgesics." The researchers conclude: "Conventional wisdom suggests that the abuse potential of opioid analgesics is such that increases in medical use of these drugs will lead inevitably to increases in their abuse. The data from this study with respect to the opioids in the class of morphine provide no support for this hypothesis. The present trend of increasing medical use of opioid analgesics to treat pain does not appear to be contributing to increases in the health consequences of opioid analgesic abuse."

April 6, 2000: The First National Clinical Conference on Cannabis Therapeutics convenes at the University of Iowa.

April 2, 2003: US Rep. Ron Paul asks the US Government Accountability Office (GAO) to investigate whether the Office of National Drug Control Policy violated the Congressional ban on spending funds on publicity or propaganda.