November 23, 1919: Mescaline is first isolated and identified by Dr. Arthur Heffter.

November 22, 1963: Aldous Huxley uses LSD to enhance his awareness as he dies.

November 22, 1975: Colombian police seize 600 kilos from a small plane at the Cali airport -- the largest cocaine seizure to date. In response, drug traffickers begin a vendetta known as the "Medellin Massacre." Forty people die in Medellin in one weekend. This event signals the new power of Colombia's cocaine industry, headquartered in Medellin.

November 24, 1976: Federal Judge James Washington rules that Robert Randall's use of marijuana constitutes a "medical necessity."

November 21, 1987: Jorge Ochoa is arrested in Colombia. Ochoa is held in prison on the bull-smuggling charge for which he was extradited from Spain. Twenty-four hours later a gang of thugs arrive at the house of Juan Gómez Martínez, the editor of Medellin's daily newspaper El Colombiano. They present Martinez with a communique signed by "The Extraditables," which threatens execution of Colombian political leaders if Ochoa is extradited. On December 30, Ochoa is released under dubious legal circumstances. In January 1988, the murder of Colombian Attorney General Carlos Mauro Hoyos is claimed by the Extraditables.

November 26, 2002: The Winston-Salem Journal (NC) reports that more than 30 drug defendants in Davidson County have had charges dismissed or convictions overturned since the officers investigating their cases were charged with distributing drugs and planting evidence.

November 20, 2009: Suffering from a rare bone disorder called multiple congenital cartilaginous exostoses, Irvin Rosenfeld marks his twenty-seventh anniversary of receiving a monthly tin of about 300 pre-rolled medical marijuana cigarettes from the United States government, as one of five living patients grandfathered into the now defunct Compassionate Investigative New Drug Program. At some point in the day he consumed his 115,000th marijuana cigarette, and set the world record for the consumption of cannabis cigarettes. All 115,000 cigarettes have been prescribed by US federally approved medical doctors from cannabis plants grown at the University of Mississippi in a test location and prepared for consumption in the research triangle area of North Carolina.