As Drug War Chronicle publishes its last issue of the year -- we will be on vacation next week -- it is time to look back at 2006. In a companion piece, we looked at the highlights for drug reform this year; here, we look at the lowlights, from failures at the polls to bad court rulings to negative trends. Below -- in no particular order -- is our necessarily somewhat arbitrary list of the ten most significant defeats and disappointments for the cause of drug law reform. (We also publish a "best of 2006" list in this issue, above.)

The drug war continues unabated on the streets of America. Despite two decades of drug reform efforts, the war on drugs continues to make America a country that eats its young. In May, we reported that the US prisoner count topped 2.1 million -- a new high -- and included more than 500,000 drug war prisoners. In September, the FBI released its annual Uniform Crime Report, showing nearly 800,000 marijuana arrests and 1.8 million drug arrests in 2005 -- another new high. And just two weeks ago, we reported that more than seven million people are in jail or prison or on probation or parole -- yet another new high.

Methamphetamine hysteria continues unabated and becomes an excuse for old-school, repressive drug laws and bad, newfangled ones, too. The drug war always needs a demon drug du jour to scare the public, and this year, like the past few years, meth is it. Never mind that the stuff has been around for decades and that there is less to the "meth epidemic" than meets the eye. The "dangers of meth" have been cited as a reason for everything from targeting South Asian convenience store clerks to restricting access to cold medications containing pseudoephedrine to harsh new penalties for meth offenses to more than 20 states defining meth use or production as child abuse. Michigan even went so far as to pass legislation banning meth recipes on the Internet, while Arizona voters felt impelled to roll back a decade-old sentencing reform. Under that reform, first- and second-time drug possession offenders couldn't be sentenced to jail or prison, but now Arizona has created an exception for meth offenders. The drug warriors like to say meth is the new crack, and in the way meth is used as an excuse for "tough" approaches to drug policy, that is certainly true.

The US Supreme Court upholds unannounced police searches. In a June decision, the court upheld a Michigan drug raid where police called out their presence at the door, but then immediately rushed in before the homeowner could respond. Previously, the courts had allowed such surprise entries only in the case of "no-knock" warrants, but this ruling, which goes against hundreds of years of common law and precedent, effectively eviscerates that distinction. "No-knock" raids are dangerous, as we reported that same month, and as Atlanta senior citizen Kathryn Johnston would tell you if she could. But she can't -- Johnston was killed in a "no-knock" raid last month.

Marijuana legalization initiatives lose in Colorado and Nevada. After four years of effort, the Marijuana Policy Project still couldn't get over the top with its "tax and regulate" initiative in Nevada, although it increased its share of the vote from 39% to 44%. In Colorado, SAFER Colorado took its "marijuana is safer than alcohol" message statewide after successes at state universities and in Denver last year, but failed to convince voters, winning only 41% of the vote.

South Dakota becomes the first state where voters defeat an initiative to legalize medical marijuana. In every state where it had gone to the voters as a ballot measure, medical marijuana had emerged victorious. But voters in the socially conservative, lightly populated Upper Midwest state narrowly rejected it in November. The measure lost 48% to 52%.

California's medical marijuana movement is under sustained attack by the feds and recalcitrant state and local officials and law enforcement. This year, it seems like barely a week goes by without a new raid by the DEA or unreconstructed drug warriors in one county or another. San Diego has been particularly hard-hit, but we also reported on a spate of raids in October, and there have been more since. The feds have also started their first medical marijuana prosecution since the 2003 Ed Rosenthal fiasco, with Merced County medical marijuana patient and provider Dustin Costa going on trial last month.

Hundreds die from overdoses of heroin cut with fentanyl, but the official response is almost nonexistent -- except for increased law enforcement pressure. With injection drug users falling over dead from Boston to Baltimore, Philadelphia to Detroit and Chicago, an estimated 700 people have been killed by the deadly cocktail. We reported on it in June, but the wave of deaths continues to the present. Just last week, more than 120 medical experts, public health departments, and drug user advocates sent a letter to Health and Human Services Secretary Mike Leavitt urging him to take aggressive action. Ho-hum, who cares about dead junkies? Not the federal government, at least so far.

Plan Colombia continues to roll along, adding fuel to the flames of Colombia's civil war while achieving little in the realm of actually reducing the supply of cocaine. The US Congress continues to fund Plan Colombia to the tune of hundreds of millions of dollars a year, even though despite six years of military assistance and widespread aerial eradication using herbicides, it now appears that production is higher than anyone ever thought. Perhaps a Democratic Congress will put an end to this fiasco next year, but Democrats certainly can count influential Plan Colombia supporters among their ranks -- incoming Senate Foreign Relations Committee chairman and presidential hopeful Joe Biden (DE), to name just one.

Afghanistan is well on its way to becoming a true narco-state. The US war on terror and the US war on drugs are on a collision course in Afghanistan, which now, five years after the US invaded, produces more than 90% of the world's illicit opium. This year, Afghanistan's opium crop hit a new record high of 6,100 metric tons, and now, US drug czar John Walters is pressuring the Afghans to embrace eradication with herbicides. But each move the US and the Afghans make to suppress the opium trade just drives more Afghans into the waiting arms of the Taliban, which is also making enough money off the trade to finance its reborn insurgency. Meanwhile, the Afghan government is also full of people getting rich off opium. Everyone is ignoring the sensible proposals that have put on the table for dealing with the problem, which range from an economic development and anti-corruption approach put forward by the UN and World Bank as an alternative to eradication, and the Senlis Council proposal to license production and divert it to the legitimate medicinal market.

Australia is in the grips of Reefer Madness. While some Australian states enacted reforms to soften their marijuana laws in years past, the government of Prime Minister John Howard would like to roll back those reforms. The Australians seem particularly susceptible to hysterical pronouncements about the links between marijuana and mental illness, and they also hold the unfathomable notion that marijuana grown hydroponically is somehow more dangerous than marijuana grown in soil. Over the weekend, the national health secretary announced he wants to ban bongs. That's not so surprising coming from a man who in May announced that marijuana is more dangerous than heroin. Hopefully, saner heads will prevail Down Under, but it isn't happening just yet.