April 3, 1953: With the support of Allen W. Dulles, director of Central Intelligence, Richard C. Helms proposes funding for a biochemical warfare research program named MKULTRA, which among other things administers LSD to its unknowing participants.

April 8, 1989: Miguel Angel Felix Gallardo is arrested in Mexico. Guillermo Gonzalez Calderoni leads a team of Federal agents who arrest the drug lord in a residential suburb of Guadalajara. Gallardo is imprisoned on charges relating to the kidnapping and murder of Enrique Camarena. His nephews, the Arellano-Felix brothers, inherit part of his drug-trafficking empire.

April 6, 1995: ABC News airs a special entitled "America's War on Drugs: Searching for Solutions" in which legalization is presented as an alternative to the failing war on drugs.

April 6, 1998: Dr. Dennis Rosenbaum's six year study of 1,798 students, "Assessing the Effects of School-based Drug Education: A Six Year Multilevel Analysis of Project DARE," finds that "DARE had no long-term effects on a wide range of drug use measures," that DARE does not "prevent drug use at the stage in adolescent development when drugs become available and widely used, namely during the high school years," and that "DARE may actually be counterproductive."

April 5, 2000: The Journal of the American Medical Association publishes "Trends in Medical Use and Abuse of Opioid Analgesics." The researchers conclude: "Conventional wisdom suggests that the abuse potential of opioid analgesics is such that increases in medical use of these drugs will lead inevitably to increases in their abuse. The data from this study with respect to the opioids in the class of morphine provide no support for this hypothesis. The present trend of increasing medical use of opioid analgesics to treat pain does not appear to be contributing to increases in the health consequences of opioid analgesic abuse."

April 6, 2000: The First National Clinical Conference on Cannabis Therapeutics convenes at the University of Iowa.

April 9, 2002: NORML launches a $500,000 campaign featuring bus shelter signs and telephone booth posters carrying a quote from New York City Mayor Michael Bloomberg, who when asked whether he had ever tried marijuana said, "You bet I did. And I enjoyed it." NORML used Bloomberg as the centerpiece of its campaign to urge the city to stop arresting and jailing people for smoking marijuana. "Millions of people smoke marijuana today. They come from all walks of life, and that includes your own mayor," said NORML Executive Director Keith Stroup.